連續兩年葛萊美獎的頒獎典禮都因為疫情而重新安排時段，典禮原先舉辦的時間是 1 月 31 日，但這次因為變種病毒的不確定性而再度更動，去年是延至 3 月 14 日，今年官方尚未公布更改之後的時間。
此外本次葛萊美獎有一項新的異動，「四大獎項」年度製作、年度專輯、年度歌曲和最佳新人的提名席位從八個名額擴大到了十個候選名單，讓競爭更加激烈，以下為本次四大獎項的入圍名單。
年度製作
- 《I Still Have Faith In You》ABBA
Benny Andersson & Björn Ulvaeus, producers; Benny Andersson & Bernard Löhr, engineers/mixers; Björn Engelmann, mastering engineer
- 《Freedom》Jon Batiste
Jon Batiste, DJ Khalil, Kizzo & Autumn Rowe, producers; Russ Elevado, Kizzo & Manny Marroquin, engineers/mixers; Michelle Mancini, mastering engineer
- 《I Get A Kick Out Of You》Tony Bennett & Lady Gaga
Dae Bennett, producer; Dae Bennett & Josh Coleman, engineers/mixers; Greg Calbi & Steve Fallone, mastering engineers
- 《Peaches》Justin Bieber Featuring Daniel Caesar & Giveon
Louis Bell, Josh Gudwin, HARV, Shndo & Andrew Watt, producers; Josh Gudwin & Andrew Watt, engineers/mixers; Colin Leonard, mastering engineer
- 《Right On Time》Brandi Carlile
Dave Cobb & Shooter Jennings, producers; Brandon Bell & Tom Elmhirst, engineers/mixers; Pete Lyman, mastering engineer
- 《Kiss Me More》Doja Cat Featuring SZA
Rogét Chahayed, tizhimself & Yeti Beats, producers; Rob Bisel, Serban Ghenea, Rian Lewis & Joe Visciano, engineers/mixers; Mike Bozzi, mastering engineer
- 《Happier Than Ever》Billie Eilish
FINNEAS, producer; Billie Eilish, FINNEAS & Rob Kinelski, engineers/mixers; Dave Kutch, mastering engineer
- 《Montero》（Call Me By Your Name）Lil Nas X
Omer Fedi, Roy Lenzo & Take A Daytrip, producers; Denzel Baptiste, Serban Ghenea, John Hanes & Roy Lenzo, engineers/mixers; Chris Gehringer, mastering engineer
- 《drivers license》Olivia Rodrigo
Daniel Nigro, producer; Mitch McCarthy & Daniel Nigro, engineers/mixers; Randy Merrill, mastering engineer
- 《Leave The Door Open》Silk Sonic
Dernst “D’Mile” Emile II & Bruno Mars, producers; Serban Ghenea, John Hanes & Charles Moniz, engineers/mixers; Randy Merrill, mastering engineer
年度專輯
- 《We Are》Jon Batiste
- 《Love For Sale》Tony Bennett & Lady Gaga
- 《Justice》（Triple Chucks Deluxe）Justin Bieber
- 《Planet Her》（Deluxe）Doja Cat
- 《Happier Than Ever》Billie Eilish
- 《Back Of My Mind》H.E.R.
- 《Montero》Lil Nas X
- 《Sour》Olivia Rodrigo
- 《Evermore》Taylor Swift
- 《Donda》Kanye West
年度歌曲
- 《Bad Habits》
Fred Gibson, Johnny McDaid & Ed Sheeran, songwriters (Ed Sheeran)
- 《A Beautiful Noise》
Ruby Amanfu, Brandi Carlile, Brandy Clark, Alicia Keys, Hillary Lindsey, Lori McKenna, Linda Perry & Hailey Whitters, songwriters (Alicia Keys & Brandi Carlile)
- 《drivers license》
Daniel Nigro & Olivia Rodrigo, songwriters (Olivia Rodrigo)
- 《Fight For You》
Dernst Emile II, H.E.R. & Tiara Thomas, songwriters (H.E.R.)
- 《Happier Than Ever》
Billie Eilish O’Connell & Finneas O’Connell, songwriters (Billie Eilish)
- 《Kiss Me More》
Rogét Chahayed, Amala Zandile Dlamini, Lukasz Gottwald, Carter Lang, Gerard A. Powell II, Solána Rowe & David Sprecher, songwriters (Doja Cat Featuring SZA)
- 《Leave The Door Open》
Brandon Anderson, Christopher Brody Brown, Dernst Emile II & Bruno Mars, songwriters (Silk Sonic)
- 《Montero》（Call Me By Your Name）
Denzel Baptiste, David Biral, Omer Fedi, Montero Hill & Roy Lenzo, songwriters (Lil Nas X)
- 《Peaches》
Louis Bell, Justin Bieber, Giveon Dezmann Evans, Bernard Harvey, Felisha “Fury” King, Matthew Sean Leon, Luis Manuel Martinez Jr., Aaron Simmonds, Ashton Simmonds, Andrew Wotman & Keavan Yazdani, songwriters (Justin Bieber Featuring Daniel Caesar & Giveon)
- 《Right On Time》
Brandi Carlile, Dave Cobb, Phil Hanseroth & Tim Hanseroth, songwriters (Brandi Carlile)
最佳新人
- Arooj Aftab
- Jimmie Allen
- Baby Keem
- FINNEAS
- Glass Animals
- Japanese Breakfast
- The Kid LAROI
- Arlo Parks
- Olivia Rodrigo
- Saweetie
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